Multimodal models integrating natural language and visual information have substantially improved generalization o f representation models. However, their effectiveness sign ifi-cantly declines in real-world situations where certain mod al-ities are missing or unavailable. This degradation primarily stems from inconsistent representation learning betwe en complete multimodal data and incomplete modality scenarios. Existing approaches typically address missing modalities through relatively simplistic generation methods, y et these approaches fail to adequately preserve cross-modal c on-sistency, leading to suboptimal performance. To overcome this limitation, we propose a novel multimodal framework named PROMISE, a PROM pting-Attentive H I erarchical ContraS tive L E arning approach designed explicitly for robust cross-modal representation under conditions of missing modalities. Specifically, PROMISE innovatively incorporates multimodal prompt learning into a hierarchical con - trastive learning framework, equipped with a specially designed prompt-attention mechanism. This mechanism dynamically generates robust and consistent representation s for scenarios where particular modalities are absent, thereby effectively bridging the representational gap between complete and incomplete data. Extensive experiments conducte d on benchmark datasets, along with comprehensive ablation studies, clearly demonstrate the superior performance of PROMISE compared to current state-of-the-art multimodal methods.

Multimodal magnetic resonance imaging (MRI) constitutes the first line of investigation for clinicians in the care of brain tumors, providing crucial insights for surgery planning, treatment monitoring, and biomarker identification. Pre-training on large datasets have been shown to help models learn transferable representations and adapt with minimal labeled data. This behavior is especially valuable in medical imaging, where annotations are often scarce. However, applying this paradigm to multimodal medical data introduces a challenge: most existing approaches assume that all imaging modalities are available during both pre-training and fine-tuning. In practice, missing modalities often occur due to acquisition issues, specialist unavailability, or specific experimental designs on small in-house datasets. Consequently, a common approach involves training a separate model for each desired modality combination, making the process both resource-intensive and impractical for clinical use. Therefore, we introduce BM-MAE, a masked image modeling pre-training strategy tailored for multimodal MRI data. The same pre-trained model seamlessly adapts to any combination of available modalities, extracting rich representations that capture both intra- and inter-modal information. This allows fine-tuning on any subset of modalities without requiring architectural changes, while still benefiting from a model pre-trained on the full set of modalities. Extensive experiments show that the proposed pre-training strategy outperforms or remains competitive with baselines that require separate pre-training for each modality subset, while substantially surpassing training from scratch on several downstream tasks. Additionally, it can quickly and efficiently reconstruct missing modalities, highlighting its practical value. Code and trained models are available at: https://github.com/Lucas-rbnt/BM-MAE

Large-scale multimodal models have shown excellent performance over a series of tasks powered by the large corpus of paired multimodal training data. Generally, they are always assumed to receive modality-complete inputs. However, this simple assumption may not always hold in the real world due to privacy constraints or collection difficulty, where models pretrained on modality-complete data easily demonstrate degraded performance on missing-modality cases. To handle this issue, we refer to prompt learning to adapt large pretrained multimodal models to handle missing-modality scenarios by regarding different missing cases as different types of input. Instead of only prepending independent prompts to the intermediate layers, we present to leverage the correlations between prompts and input features and excavate the relationships between different layers of prompts to carefully design the instructions.

Multi-modal recommender systems (MRSs) have achieved notable success in improving personalization by leveraging diverse modalities such as images, text, and audio. However, two key challenges remain insufficiently addressed: (1) Insufficient consideration of missing modality scenarios and (2) the overlooking of unique characteristics of modality features. These challenges result in significant performance degradation in realistic situations where modalities are missing. To address these issues, we propose Disentangling and Generating Modality Recommender (DGMRec), a novel framework tailored for missing modality scenarios. DGMRec disentangles modality features into general and specific modality features from an information-based perspective, enabling richer representations for recommendation. Building on this, it generates missing modality features by integrating aligned features from other modalities and leveraging user modality preferences. Extensive experiments show that DGMRec consistently outperforms state-of-the-art MRSs in challenging scenarios, including missing modalities and new item settings as well as diverse missing ratios and varying levels of missing modalities. Moreover, DGMRec's generation-based approach enables cross-modal retrieval, a task inapplicable for existing MRSs, highlighting its adaptability and potential for real-world applications. Our code is available at https://github.com/ptkjw1997/DGMRec.

Joint analysis of multi-omic single-cell data across cohorts has significantly enhanced the comprehensive analysis of cellular processes. However, most of the existing approaches for this purpose require access to samples with complete modality availability, which is impractical in many real-world scenarios. In this paper, we propose (Single-Cell Cross-Cohort Cross-Category) integration, a novel framework that learns unified cell representations under domain shift without requiring full-modality reference samples. Our generative approach learns rich cross-modal and cross-domain relationships that enable imputation of these missing modalities. Through experiments on real-world multi-omic datasets, we demonstrate that offers a robust solution to single-cell tasks such as cell type clustering, cell type classification, and feature imputation.

In real-world scenarios, multimodal federated learning often faces the practical challenge of intricate modality missing, which poses constraints on building federated frameworks and significantly degrades model inference accuracy. Existing solutions for addressing missing modalities generally involve developing modality-specific encoders on clients and training modality fusion modules on servers. However, these methods are primarily constrained to specific scenarios with either unimodal clients or complete multimodal clients, struggling to generalize effectively in the intricate modality missing scenarios. In this paper, we introduce a prototype library into the FedAvg-based Federated Learning framework, thereby empowering the framework with the capability to alleviate the global model performance degradation resulting from modality missing during both training and testing. The proposed method utilizes prototypes as masks representing missing modalities to formulate a task-calibrated training loss and a model-agnostic uni-modality inference strategy. In addition, a proximal term based on prototypes is constructed to enhance local training. Experimental results demonstrate the state-of-the-art performance of our approach. Compared to the baselines, our method improved inference accuracy by 3.7\% with 50\% modality missing during training and by 23.8\% during uni-modality inference. Code is available at https://github.com/BaoGuangYin/PmcmFL.

Multimodal learning seeks to utilize data from multiple sources to improve the overall performance of downstream tasks. It is desirable for redundancies in the data to make multimodal systems robust to missing or corrupted observations in some correlated modalities. However, we observe that the performance of several existing multimodal networks significantly deteriorates if one or multiple modalities are absent at test time. To enable robustness to missing modalities, we propose simple and parameter-efficient adaptation procedures for pretrained multimodal networks. In particular, we exploit low-rank adaptation and modulation of intermediate features to compensate for the missing modalities. We demonstrate that such adaptation can partially bridge performance drop due to missing modalities and outperform independent, dedicated networks trained for the available modality combinations in some cases. The proposed adaptation requires extremely small number of parameters (e.g., fewer than 0.7% of the total parameters in most experiments). We conduct a series of experiments to highlight the robustness of our proposed method using diverse datasets for RGB-thermal and RGB-Depth semantic segmentation, multimodal material segmentation, and multimodal sentiment analysis tasks. Our proposed method demonstrates versatility across various tasks and datasets, and outperforms existing methods for robust multimodal learning with missing modalities.

Despite many efforts to address the disparities, the underrepresentation of gender, racial, and ethnic minorities in clinical trials remains a problem and undermines the efficacy of treatments on minorities. This paper focuses on the trial site selection task and proposes FRAMM, a deep reinforcement learning framework for fair trial site selection. We focus on addressing two real-world challenges that affect fair trial sites selection: the data modalities are often not complete for many potential trial sites, and the site selection needs to simultaneously optimize for both enrollment and diversity since the problem is necessarily a trade-off between the two with the only possible way to increase diversity post-selection being through limiting enrollment via caps. To address the missing data challenge, FRAMM has a modality encoder with a masked cross-attention mechanism for handling missing data, bypassing data imputation and the need for complete data in training. To handle the need for making efficient trade-offs, FRAMM uses deep reinforcement learning with a specifically designed reward function that simultaneously optimizes for both enrollment and fairness. We evaluate FRAMM using 4,392 real-world clinical trials ranging from 2016 to 2021 and show that FRAMM outperforms the leading baseline in enrollment-only settings while also achieving large gains in diversity. Specifically, it is able to produce a 9% improvement in diversity with similar enrollment levels over the leading baselines. That improved diversity is further manifested in achieving up to a 14% increase in Hispanic enrollment, 27% increase in Black enrollment, and 60% increase in Asian enrollment compared to selecting sites with an enrollment-only model.

Multimodal electronic health record (EHR) data are widely used in clinical applications. Conventional methods usually assume that each sample (patient) is associated with the unified observed modalities, and all modalities are available for each sample. However, missing modality caused by various clinical and social reasons is a common issue in real-world clinical scenarios. Existing methods mostly rely on solving a generative model that learns a mapping from the latent space to the original input space, which is an unstable ill-posed inverse problem. To relieve the underdetermined system, we propose a model solving a direct problem, dubbed learning with Missing Modalities in Multimodal healthcare data (M3Care). M3Care is an end-to-end model compensating the missing information of the patients with missing modalities to perform clinical analysis. Instead of generating raw missing data, M3Care imputes the task-related information of the missing modalities in the latent space by the auxiliary information from each patient's similar neighbors, measured by a task-guided modality-adaptive similarity metric, and thence conducts the clinical tasks. The task-guided modality-adaptive similarity metric utilizes the uncensored modalities of the patient and the other patients who also have the same uncensored modalities to find similar patients. Experiments on real-world datasets show that M3Care outperforms the state-of-the-art baselines. Moreover, the findings discovered by M3Care are consistent with experts and medical knowledge, demonstrating the capability and the potential of providing useful insights and explanations.

Multimodal learning has achieved great successes in many scenarios. Compared with unimodal learning, it can effectively combine the information from different modalities to improve the performance of learning tasks. In reality, the multimodal data may have missing modalities due to various reasons, such as sensor failure and data transmission error. In previous works, the information of the modality-missing data has not been well exploited. To address this problem, we propose an efficient approach based on maximum likelihood estimation to incorporate the knowledge in the modality-missing data. Specifically, we design a likelihood function to characterize the conditional distribution of the modality-complete data and the modality-missing data, which is theoretically optimal. Moreover, we develop a generalized form of the softmax function to effectively implement maximum likelihood estimation in an end-to-end manner. Such training strategy guarantees the computability of our algorithm capably. Finally, we conduct a series of experiments on real-world multimodal datasets. Our results demonstrate the effectiveness of the proposed approach, even when 95% of the training data has missing modality.